San Francisco at Denver
Time: 8:30 PM (ET)
Network: NBC
The game of the week is without a question the San Francisco 49ers facing an inter-conference match-up against the Denver Broncos. Most will say this is a Super Bowl meeting that should’ve happened at least once in the last two seasons and could be the fate of this year’s outcome. Following a tough road win in St. Louis where they defeated the Rams 31-17, the 49ers are back on short rest this time at Sports Authority Field at Mile High against Peyton Manning and his Broncos. Outside of the primetime match-up, Peyton Manning just needs three touchdowns to pass Brett Favre for the all-time touchdown completions list at 508. DeMarcus Ware and Von Miller will have the task of containing Colin Kaepernick, which we expect them route a fatigued 49ers team. However, a victory today here from San Francisco could send a shockwave through the entire NFL heading forward.