Legend, westside!
While 2pac and Jay-Z never collaborated, the two were in the same room in the mid-90s. Before Pac was set up for a fake rape case, shot in NYC by informants and then later assassinated by people in charge; he was in Manhattan at an event. Jay-Z happened to be there and wanted to briefly introduce himself. Unfortunately, Pac, who was always on the move, missed Jay by a few seconds, as the story is told in full below.