Francois Botha | January 16, 1999 | MGM Grand Garden Arena, Las Vegas
Outcome: Fifth Round Knockout | 2:59
After being upset two consecutive times to Evander Holyfield for the WBA Heavyweight title; 2 years later it was 1999 as Tyson was ready to hit the ring restart his career with his first match back in Vegas at MGM after his WWF stint against Francois Botha who was 39-1 at the time of his 9 year career.
Unlike his other knockouts, Tyson would have to wait until the 5th round as Botha would run out of gas and before the conclusion of the round, Tyson would hit him right between the eyes with one right hand to knockout Botha. Francois would stumble up trying to recover but it was too late as he would fall victim to Iron Mike.